"After testing many candidate regions, the researchers localized the effects of hallucinogens to the pyramidal neurons in layer V of the somatosensory cortex, a relatively high-level region known to modulate the activity of other sections in the cortex and subcortical areas."
via:
sciam
no subject
Understanding the precise mechanisms will eventually make for some much more targeted halluinogens and devices as well. In a few decades more, one will be able to choose one's hallucinations!